Mersana to share interim data of XMT-1536 from ongoing Phase 1 trial
Category: #health  By Pankaj Singh  Date: 2019-06-03
  • share
  • Twitter
  • Facebook
  • LinkedIn

Mersana to share interim data of XMT-1536 from ongoing Phase 1 trial

Clinical-stage biopharmaceutical company Mersana Therapeutics, Inc. has reportedly presented interim efficiency and safety data from its current Phase 1 dose-escalation study evaluating its first-in-class ADC candidate XMT-1536 aimed at NaPi2b, in patients suffering from non-small cell lung (NSCLC) adenocarcinoma, ovarian cancer, and other tumor types. As per trusted sources, the data will be exhibited in a poster session and poster discussion at the 2019 American Society of Clinical Oncology Annual Meeting.

Among the 37 registered patients the tumor types observed include 22 ovarian, primary peritoneal or fallopian tube cancer, eight endometrial, two papillary renal, four NSCLC and one salivary duct cancer. Patients received heavy pre-treatment through a median of 4 prior lines of treatment (range 1-13) for the entire group of patients and a median of 5 lines of pre-treatment for ovarian cancer patients (range 1-11), cited sources close to the development. 

According to sources familiar with the interim results, the most common TRAEs were Grade 1-2 nausea, headache, fatigue and the most frequent Grade-3 TRAE was transient AST elevation. Among patients with tumor types chosen for the strategic expansion phase, specifically NSCLC adenocarcinoma and platinum-resistant ovarian cancer, treated with ≥20 mg/m2 (N=18), 17% showed partial responses and 44% attained stable disease demonstrating a disease control rate of 11/18 (61%), with the treatment period lasting for more than 16 weeks in 9 patients.

Mersana Therapeutics continues to assess patients in the dose escalation period of the clinical trial within the 36 mg/m2 once-every-four-week dose level. On completing the 36 mg/m2 evaluation, the dose that the company expects to go with for the study’s dose expansion phase will be either the 30 mg/m2 dose or the 36 mg/m2 every four weeks dose levels. Moreover, the company is also planning on dosing patients during the dose expansion phase within the third quarter of 2019, reported sources.

Source Credit
http://ir.mersana.com/news-releases/news-release-details/mersana-presents-interim-phase-1-data-xmt-1536-2019-american

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Pankaj Singh    

Pankaj Singh

With an experience as an insurance underwriter and a freelance writer under his belt, Pankaj Singh boasts of quite some expertise in the field of content creation. A qualified Post Graduate in Management, Pankaj has also completed a detailed course in Digital Marketin...

Read More

More News By Pankaj Singh

Genentech reveals submission of sBLA to FDA for Tecentriq-Avastin
Genentech reveals submission of sBLA to FDA for Tecentriq-Avastin
By Pankaj Singh

Genentech, Inc., a subsidiary of the Roche Group, has reportedly announced the completion of a sBLA (supplemental Biologics License Application) submission to the U.S. FDA (Food and Drug Administration) for Tecentriq ® (atezolizumab) in combinati...

FDA issues a cybersecurity warning for GE medical equipment
FDA issues a cybersecurity warning for GE medical equipment
By Pankaj Singh

The U.S. Food and Drug Administration, an agency within the U.S. Department of Health and Human Services, recently issued a safety communication informing patients, health care providers and facilities regarding the cybersecurity vulnerabilities...

French-Belgian biotech PDC*LINE bags USD 22.2M in a Series B funding
French-Belgian biotech PDC*LINE bags USD 22.2M in a Series B funding
By Pankaj Singh

A clinical stage biotechnology company, PDC*line Pharma, focused upon developing a new class of effective and scalable active immunotherapies for treating cancers, recently announced completion of a Series B round of funding. The company ha...