TSI finalizes Phase 2 Study Protocol in Myocardial infarction
Category: #health  By Mateen Dalal  Date: 2019-11-01
  • share
  • Twitter
  • Facebook
  • LinkedIn

TSI finalizes Phase 2 Study Protocol in Myocardial infarction

Myocardial infarction (MI), commonly known as heart attack, occurs due to decrease in blood flow that damages heart muscles. Currently, MI treatment varies from making changes in lifestyle to medication and bypass surgeries. However, various pharmaceutical firms are making some groundbreaking advancements to develop novel clinical therapies for MI. Thrombolytic Science, LLC (TSI) is one such company that has made tremendous development in this field.

Recently, the company revealed that it has successfully made progress with 10 subjects registered in its randomized, prospective, multicenter Phase 2 clinical study, developed to confirm the efficacy and safety of sequential dual-treatment regimen of low-dose HisproUK and tPA (tissue plasminogen activator) in 200 patients that suffer from ischemic stroke.

Reportedly, the study is being led by Erasmus MC Stroke Center’s co-director, Prof. Diederik Dippel. In addition to this, TSI has also announced finalizing the protocol for a multicenter Phase 2 trial in 100 myocardial infarction patients and is expected to enroll its patients in Ukraine by Q1 of 2020.

Apparently, both MI and ischemic stroke are triggered by a blood clot. To regain adequate blood flow, the primary pharmacological treatment currently available consists of dissolving the clot, or thrombolysis, as fast as possible by infusing a dose of tPA, a single natural enzyme. However, studies indicate that natural thrombolysis is achieved by a sequence of tPA plus a second enzyme called proUK.

Speaking on the move, Alexis Wallace, MScEng, MBA, Co-founder and CEO, TSI, said that the company is on schedule with recruitment and initiation for both of its Phase 2 clinical studies that focus on comparing the TSI dual-therapy regimen against the standards regimen in each indication.

Wallace added that their firm has recorded inquiries from probable pharmaceutical partners and is expecting to further their discussions as it advances its clinical programs to improve the treatment of heart attacks and strokes.
 

Source Credit: https://www.b3cnewswire.com/201910301993/tsi-reports-enrollment-of-first-10-patients-in-its-phase-2-ischemic-stroke-clinical-trial-and-completion-of-its-phase-2-study-protocol-in-myocardial-infarction.html

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

PayPal buys Happy Returns to strengthen reverse logistics system
PayPal buys Happy Returns to strengthen reverse logistics system
By Mateen Dalal

U.S. based digital payments platform, PayPal, an online payment system entity has announced the purchase of Happy Returns- a returns solution firm that provides online buyers access to simplified ways to return unwanted merchandise to retailers; elim...

YOP officially unveils YOP app to ease access to DeFi for the masses
YOP officially unveils YOP app to ease access to DeFi for the masses
By Mateen Dalal

Yield Optimization Platform and Protocol (YOP) recently declared its official launch of YOP application; the first all-in-one mobile app which makes it quite easier for everyone to access DeFi. The V0 version of the app is now available for early acc...

Singapore to create second national supercomputer with more on roadmap
Singapore to create second national supercomputer with more on roadmap
By Mateen Dalal

Following its success of the first supercomputer system, Singapore is set to build its upcoming second supercomputer system in an attempt to strengthen the local research community, offering 8X more computing capacity than its previous model. The sy...