Takeda Pharma unveils new TOURMALINE-AL1 Phase-3 clinical trial update
Category: #health  By Mateen Dalal  Date: 2019-06-07
  • share
  • Twitter
  • Facebook
  • LinkedIn

Takeda Pharma unveils new TOURMALINE-AL1 Phase-3 clinical trial update

· The company announced that the clinical trial failed to fulfil the first of the two preestablished endpoints.

· Citing the result of the analysis, Takeda Pharma has decided to permanently halt the trial.

Takeda Pharmaceutical Company Ltd. (Takeda Pharma), a renowned Japanese pharmaceutical company, has reportedly released a new update on its ongoing Phase-3 TOURMALINE-AL1 clinical trial in individuals suffering from refractory or relapsed systemic light-chain amyloidosis.

Reports cite, the clinical trial failed to fulfil the first of the two preestablished endpoints, wherein an assessment of treatment through a combination of dexamethasone & NINLAROTM (ixazomib).

According to a report by Financial Post, the combination treatment failed to demonstrate any substantial improvement in the patients overall hematologic response as compared to a physician’s preferred standard of care.

The Head of Oncology Therapeutic Area Unit at Takeda, Phil Rowlands, Ph.D., stated that while the company is disappointed with the outcome of the trial, it still aims to maximize its own learnings from the trial and further share any findings with the community with the intention that it would help improve care for individuals that are living with the debilitating disease.

The trial was one of the biggest studies to be ever conducted for systemic light-chain AL amyloidosis, demonstrating the company’s dedication in finding a cure for the rare disease with a patient population that is conventionally difficult to enroll.

Meanwhile, the company remains optimistic regarding NINLARO as an individual entity and would continue to investigate the candidate in patients across the sequence of multiple-myeloma care.

While an Independent Data Monitoring Committee (IDMC) has not raised any concerns about NINLARO’s safety, patients are still encouraged to approach their respective study investigators to address any queries.

According to reports, citing the result of the dexamethasone & NINLARO combination treatment analysis, Takeda Pharma has decided to permanently halt the clinical trial.

Source Credit: https://www.takeda.com/newsroom/newsreleases/2019/takeda-provides-update-on-tourmaline-al1-phase-3-trial/

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

NantHealth & NantOmics launch AI platform for subtyping Lung Cancer
NantHealth & NantOmics launch AI platform for subtyping Lung Cancer
By Mateen Dalal

NantHealth, Inc., a personalized, evidence-based, next-generation healthcare company and NantOmics, LLC, one of the leading companies in molecular analysis, have reportedly launched an innovative AI platform for assisting pathologists in image-based ...

Air France-KLM & JAL make bids to purchase stake in Malaysia Airlines
Air France-KLM & JAL make bids to purchase stake in Malaysia Airlines
By Mateen Dalal

Air France–KLM S.A., one of the leading global air transport players, has reportedly made a proposal to invest in Malaysia Airlines and gain around 49 percent stake. Japan Airlines (JAL) is also looking to acquire a 25 percent stake in Mal...

Accenture opens innovation center in South Beach Road office
Accenture opens innovation center in South Beach Road office
By Mateen Dalal

Accenture, an Irish multinational professional services company, has recently opened a global innovation center within the Accenture’s office at South Beach Road, which is supported by EDB (Economic Development Board) in Singapore. It will pro...