Takeda Pharma unveils new TOURMALINE-AL1 Phase-3 clinical trial update
Category: #health  By Mateen Dalal  Date: 2019-06-07
  • share
  • Twitter
  • Facebook
  • LinkedIn

Takeda Pharma unveils new TOURMALINE-AL1 Phase-3 clinical trial update

· The company announced that the clinical trial failed to fulfil the first of the two preestablished endpoints.

· Citing the result of the analysis, Takeda Pharma has decided to permanently halt the trial.

Takeda Pharmaceutical Company Ltd. (Takeda Pharma), a renowned Japanese pharmaceutical company, has reportedly released a new update on its ongoing Phase-3 TOURMALINE-AL1 clinical trial in individuals suffering from refractory or relapsed systemic light-chain amyloidosis.

Reports cite, the clinical trial failed to fulfil the first of the two preestablished endpoints, wherein an assessment of treatment through a combination of dexamethasone & NINLAROTM (ixazomib).

According to a report by Financial Post, the combination treatment failed to demonstrate any substantial improvement in the patients overall hematologic response as compared to a physician’s preferred standard of care.

The Head of Oncology Therapeutic Area Unit at Takeda, Phil Rowlands, Ph.D., stated that while the company is disappointed with the outcome of the trial, it still aims to maximize its own learnings from the trial and further share any findings with the community with the intention that it would help improve care for individuals that are living with the debilitating disease.

The trial was one of the biggest studies to be ever conducted for systemic light-chain AL amyloidosis, demonstrating the company’s dedication in finding a cure for the rare disease with a patient population that is conventionally difficult to enroll.

Meanwhile, the company remains optimistic regarding NINLARO as an individual entity and would continue to investigate the candidate in patients across the sequence of multiple-myeloma care.

While an Independent Data Monitoring Committee (IDMC) has not raised any concerns about NINLARO’s safety, patients are still encouraged to approach their respective study investigators to address any queries.

According to reports, citing the result of the dexamethasone & NINLARO combination treatment analysis, Takeda Pharma has decided to permanently halt the clinical trial.

Source Credit: https://www.takeda.com/newsroom/newsreleases/2019/takeda-provides-update-on-tourmaline-al1-phase-3-trial/

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

Telenor to sell stake in Myanmar's Wave Money for $53 Mn to Yoma
Telenor to sell stake in Myanmar's Wave Money for $53 Mn to Yoma
By Mateen Dalal

Telenor Group, an international provider of tele, data and media communication services, has reportedly agreed to sell its 51% stake in Myanmar's Wave Money, a provider of digital payment service, for $53 million to Yoma MFS Holdings, a subsidiar...

Alkem to launch state-of-the-art technology to treat DFU in India
Alkem to launch state-of-the-art technology to treat DFU in India
By Mateen Dalal

Alkem Laboratories Ltd. (Alkem), an Indian multinational pharmaceutical company, has reportedly launched a unique patented technology for the treatment of Diabetic Foot Ulcer (DFU) in India. The solution would be based on an innovative technology of...

Bank of America unveils new drive-thru ATM; shuts another in Bethlehem
Bank of America unveils new drive-thru ATM; shuts another in Bethlehem
By Mateen Dalal

According to Andy Aldridge, Bank of America Spokesperson, the financial institutiThe Bank of America Corporation, an American multinational investment bank and financial services, has now opened up a new place for clients in North Bethlehem who are l...