SELLAS doses first patient in study of GPS and KEYTRUDA® combination
Category: #health  By Mateen Dalal  Date: 2019-08-02
  • share
  • Twitter
  • Facebook
  • LinkedIn

SELLAS doses first patient in study of GPS and KEYTRUDA® combination

The trial involves patients diagnosed with acute myeloid leukemia and colorectal, ovarian, triple negative breast and small cell lung cancers.

SELLAS Life Sciences Group, Inc., a biopharmaceutical company focusing on the development of cancer immunotherapies to address a varied cancer indications, has reportedly announced the dosing of the first patient for its Phase 1/2 open-label trial of GPS combined with KEYTRUDA, Merck’s anti-PD-1 therapy, to patients diagnosed with WT1-positive advanced cancers including hematologic and solid tumor malignances.

According to Angelos M. Stergiou, President and CEO at SELLAS, the study facilitates enhancement of safety and activity portfolio of GPS coupled with anti – PD-1 therapies, specifically combined with KEYTRUDA in several malignances, following initial combination clinical data with OPDIVO. Additionally, the WT1 immunotherapeutic, GPS, together with anti PD-1 immunotherapy agents may prove beneficial in the treatment of cancer, he further claimed.

As per a statement by the company, the co-principal investigators of the study are - Richard Maziarz, MD and Medical Director of the Adult Bone Marrow Stem Cell Transplant and Cellular Therapy at Knight Cancer Institute, and Roisin O’Cearbhaill, M.D., the Assistant Attending Physician in Gynecological Medical Oncology Service for Memorial Sloan Kettering Cancer Center.

Reportedly, the first clinical data from the study will be available by the first quarter of 2020.

SELLAS Life Sciences Group, Inc. is a biopharma-based company focusing on the cancer immunotherapeutics for a wide range of cancer related symptoms. The company’s leading product, GPS has been licensed from Memorial Sloan Kettering Cancer Centre in the U.S. and attacks the Wilms Tumor 1 protein that is vividly present in numerous types of tumors.

The trial is taking place across 20 states in the U.S. and would involve approximately 90 patients. Initially, the study will evaluate patients diagnosed with ovarian cancer and colorectal cancer followed by patients with acute myeloid leukemia, who cannot undergo stem cell transplant and those who cannot attain deeper morphological response than partial on hypomethylating agents, as well as patients with triple negative breast cancer and small cell lung cancer.

 

Source Credits : https://www.sellaslifesciences.com/investors/news/News-Details/2019/SELLAS-Advances-Galinpepimut-S-GPS-in-Combination-with-KEYTRUDA-pembrolizumab-Program-with-Dosing-of-First-Patient-in-Phase-12-Basket-Study/default.aspx

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

US senator pleas investigation over TikTok’s Musical.ly acquisition
US senator pleas investigation over TikTok’s Musical.ly acquisition
By Mateen Dalal

Musical.ly is a social media service which was released in 2014 in Shanghai and is incorporated in Santa Monica, California. The service was acquired by ByteDance and has been operating as TikTok for overseas markets. However, the viral social media...

Midatech initiates Phase 1 trial of a new hormonal cancer therapy
Midatech initiates Phase 1 trial of a new hormonal cancer therapy
By Mateen Dalal

Cancer treatment is one of the biggest challenges for the 21st century. There have been many advancements in the field of cancer treatment over the past few years. Clinical trial indeed plays a pivotal role in discovering new drugs, especially for tr...

DISH Network inks Multi-Year Carriage Agreement with Fox Corp.
DISH Network inks Multi-Year Carriage Agreement with Fox Corp.
By Mateen Dalal

Sports channels are one of the few types of TV broadcasts that people prefer live. No channel is more vital to sports fans than a regional sports network that views their favorite teams. However, a dispute emerged recently between Dish Network and Fo...