Precigen Inc. doses first patient in study of advanced cancer therapy
Category: #health  By Mateen Dalal  Date: 2019-08-06
  • share
  • Twitter
  • Facebook
  • LinkedIn

Precigen Inc. doses first patient in study of advanced cancer therapy

PRGN-3005 UltraCAR-T is a type of multigenic CAR-T cell therapy which utilizes Precigens advanced non-viral gene delivery system

Precigen Inc, a biopharmaceutical company and a wholly owned subsidiary of Intrexon Corporation, has recently confirmed that the first patient has been dosed with PRGN-3005, Precigens first in class investigational therapy using the UltraCAR-T™ therapeutic platform of the company.

Apparently, Precigen's PRGN-3005 ULTRACAR-T is a chimeric antigen receptor T cell therapy produced through non-viral gene delivery and is under investigation for the treatment of patients having advanced, recurrent ovarian, fallopian tube or primary peritoneal cancer that is platinum resistant.

Sources familiar with the matter mentioned that PRGN-3005 could utilize transformative UltraCAR-T therapeutic platform, which is designed to eliminate ex vivo expansion and lower manufacturing time to enable rapid next day UltraCAR-T cells administration subsequently following a non-viral gene transfer. 

Seemingly, PRGN-3005 UltraCAR-T is a type of multigenic CAR-T cell investigational therapy which utilizes advanced non-viral gene delivery system of Precigen, to co-express a membrane-bound interleukin15 chimeric antigen receptor, and a kill switch for better control and precision.

According to President of Precigen, Helen Sabzevari, PhD, this is a vital milestone in company’s efforts to develop a new treatment choice for patients with ovarian cancer. With the initial ovarian cancer patient dosed with PRGN-3005 UltraCAR-T investigational therapy, the company remains committed towards its goal of delivering significant new therapies for solid tumor patients with great unmet need.

Supposedly, conducted in partnership with Fred Hutchinson Cancer Research Center and the University of Washington, the PRGN-3005 UltraCAR-T clinical trial is an open-label and a first in human Phase 1 dosage escalation study to examine the safety and maximal tolerated dosage of PRGN-3005 UltraCAR-T delivered by intravenous infusion or intraperitoneal infusion.

The study population will include patients with advanced stage recurrent primary peritoneal, fallopian tube, ovarian cancer who are platinum-resistant and have progressed despite getting standard of care therapies or are not suitable to receive available therapies with substantial known clinical benefit.

Source Credits: https://www.prnewswire.com/news-releases/precigen-announces-first-patient-dosed-in-phase-1-study-of-prgn-3005-ultracar-t-in-patients-with-advanced-recurrent-platinum-resistant-ovarian-fallopian-tube-or-primary-peritoneal-cancer-300896084.html?tc=eml_cleartime

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

Telenor to sell stake in Myanmar's Wave Money for $53 Mn to Yoma
Telenor to sell stake in Myanmar's Wave Money for $53 Mn to Yoma
By Mateen Dalal

Telenor Group, an international provider of tele, data and media communication services, has reportedly agreed to sell its 51% stake in Myanmar's Wave Money, a provider of digital payment service, for $53 million to Yoma MFS Holdings, a subsidiar...

Alkem to launch state-of-the-art technology to treat DFU in India
Alkem to launch state-of-the-art technology to treat DFU in India
By Mateen Dalal

Alkem Laboratories Ltd. (Alkem), an Indian multinational pharmaceutical company, has reportedly launched a unique patented technology for the treatment of Diabetic Foot Ulcer (DFU) in India. The solution would be based on an innovative technology of...

Bank of America unveils new drive-thru ATM; shuts another in Bethlehem
Bank of America unveils new drive-thru ATM; shuts another in Bethlehem
By Mateen Dalal

According to Andy Aldridge, Bank of America Spokesperson, the financial institutiThe Bank of America Corporation, an American multinational investment bank and financial services, has now opened up a new place for clients in North Bethlehem who are l...