Innate Pharma features innovative cancer immunotherapies at AACR 2019
Category: #health  By Mateen Dalal  Date: 2019-04-01
  • share
  • Twitter
  • Facebook
  • LinkedIn

Innate Pharma features innovative cancer immunotherapies at AACR 2019

New data describes that a combination of Innate’s anti-CD39 monoclonal antibody and ATP-inducing oxaliplatin had enhanced the control of tumor growth

Innate Pharma has reportedly announced that new preclinical data from the innovative portfolio of the company’s next generation cancer immunotherapies has been unveiled at a conference session at the American Association for Cancer Research Annual Meeting, organized from 29th March to 3rd April in the Atlanta city.

Seemingly, the CD73 and CD39 are membrane-bound extracellular enzymes playing a vital role in advancing immunosuppression through the adenosine triphosphate (ATP) into immunosuppressive adenosine (Ado). The blockade of CD73 and CD39 has the capability of promoting anti-tumor immune responses across a broad tumor range.

Innate Pharma mentioned that the new data describes a combination of IPH5201, its anti-CD39 monoclonal antibody, and ATP-inducing oxaliplatin had synergistic outcomes to enhance the control of tumor growth. In addition, CD73/IPH5301 complex’s crystal structure showed data that supports a type of differentiated mode of IPH5301 action and enhanced efficacy as compared to competitors.

The studies using electron microscopy revealed that the IPH5301 monoclonal antibody links mainly with CD73 dimer in an intra-dimer phase, limiting the CD73 enzyme that is in an inactive state in which AMP could not be hydrolyzed, in comparison to other antibodies in development phase.

In 2018, the findings which were presented at American Association of Cancer Research (AACR) conference described that IPH5301 is more capable in vitro in comparison to anti-CD73 antibodies presently under clinical development on both soluble CD73 and membrane-bound in T cell proliferation assays and enzymatic activity.

Apparently, Innate is expecting INDs to be filed for IPH5301 in the first half of 2020 and IPH5201 in the second half of 2019. 

For the record, Innate Pharma has a licensing agreement and research collaboration with Sanofi regarding the evaluation and generation of up to two multifunctional NK cell engagers using technology of both companies and tumor targets. Under the agreements, Sanofi is responsible for manufacturing, commercialization and products development while Innate Pharma is eligible for €400m in commercialization payments and development and royalties on net sales.

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

UAE extends travel ban for Indians amid strict COVID-19 guidelines
UAE extends travel ban for Indians amid strict COVID-19 guidelines
By Mateen Dalal

United Arab Emirates (UAE) has reportedly extended travel ban for individuals travelling from India and several other south Asian countries on the pretext of COVID-19 guidelines. As reported by Etihad Airlines, the ban will be followed till 31st July...

Adevinta Ventures backs Lovys's Series A follow-on investment round
Adevinta Ventures backs Lovys's Series A follow-on investment round
By Mateen Dalal

Adevinta Ventures, an investment arm of Adevinta, has announced its investment in French insurance service provider ‘Lovys’, marking as its first investment in France in the Fintech and Insurtech sector. With this investment, Adevinta Ve...

Indian EV startup eBikeGo expands fleet to 2,100, hires 70 employees
Indian EV startup eBikeGo expands fleet to 2,100, hires 70 employees
By Mateen Dalal

The company is aiming for achieving a 2% share in the Indian electric two-wheeler market, with plans to deploy 200,000 e-scooters across 100 cities eBikeGo, an electric vehicle startup, has recently revealed that it has increased its fleet of electr...