Dance Biopharm unveils positive Phase 2 trial data for inhaled insulin

The new data further supports the potential of Dance 501 inhaled insulin in Type 2 diabetes patients

Dance Biopharm Holdings, Inc has recently presented Phase 2 Samba 04 clinical study results for its preservative free inhaled human insulin, Dance 501, for the treatment of Type 2 diabetes. Dance Biopharm is a privately-owned clinical stage biopharma company fully focused on the development of a new soft mist inhalable biologic formulations for those people suffering from chronic diseases.

Seemingly, in the results Dance 501 showed a faster onset of action for as compared to similar doses of subcutaneously administered insulin lispro. These findings were to be presented at the 79th Scientific Sessions of the American Diabetes Association, being organized in San Francisco.

According to Anne Whitaker, the chief executive officer of Dance Biopharm, the company’s presentation at ADA underscores ongoing commitment of Dance to develop advanced and patient-focused inhaled therapies that result to better health outcomes for people suffering with chronic diseases like diabetes.

Whitaker said that the new data further supports the potential of Dance 501, inhaled preservative free human inhaled insulin, which is an alternate treatment to injectable insulin for diabetes. These data determine the outstanding performance of soft mist inhaler platform and encourages the company to swiftly progress the development of its innovative soft mist biologics portfolio as treatments for chronic and severe diseases, Whitaker mentioned.

Sources familiar with the matter informed that this Phase 2 clinical trial, Samba 04, was designed as an open label, crossover, randomized, and active-comparator-controlled study that recruited 24 subjects with type 2 diabetes presently receiving metformin or insulin therapy. Each patient got three doses of subcutaneous insulin lispro and three doses of inhaled Dance 501 under medical administration or supervision.

Apparently, doses administered were 12, 24 and 48 U for both lispro and Dance 501. Each patient received all 6 doses during 6 visits that occurred 3 to 17 days apart. Using the automated glucose clamp method, insulin action was measured over a 10-hour period following dosing.

 

Source Credit: https://www.dancebiopharm.com/investors-and-media/press-releases/detail/18/dance-biopharm-presents-encouraging-data-from-phase-2