Cara begins Phase 2 trial of pruritus treatment in dermatitis patients
Category: #health  By Mateen Dalal  Date: 2019-07-11
  • share
  • Twitter
  • Facebook
  • LinkedIn

Cara begins Phase 2 trial of pruritus treatment in dermatitis patients

The study is formulated to evaluate the safety and efficacy of Oral KORSUVA for moderate to severe pruritus

Biopharmaceutical firm Cara Therapeutics Inc. has reportedly announced the initiation of their Phase 2 trial of Oral KORSUVATM for pruritus treatment in patients diagnosed with atopic dermatitis (AD). Evidently, AD is one of the leading chronic inflammatory diseases with occurrence rates of close to 25% in children and approximately 5% in adults.

Dr. Derek Chalmers, Cara President and CEO, was quoted saying that pruritus is a key defining feature of AD that considerably affects patients’ quality of life. He added that the company looks forward to initiating the Phase 2 trial to evaluate Oral KORSUVA as a potential oral treatment option for the treatment of pruritus.

Apparently, the Phase 2 randomized, placebo-controlled, double-blind study is formulated to evaluate the safety and efficacy of Oral KORSUVA for moderate to severe pruritus in 240 adult patients having AD. The subjects will be randomly administered with three tablet strengths of the drug, 0.25mg, 0.5mg and 1mg, taken twice daily vs. placebo for 12 weeks followed by a 4-week active extended phase.

Sources familiar with the study reported that the primary efficacy endpoint will be the change from reference point in the weekly mean of the 24hour I-NRS score at week 12. Whereas the secondary endpoints includes change from starting point in itch-related scores at the end of the 12th week as evaluated by Skindex 5-D and 10 itch scales, as well as the number of patients reaching baseline of more than or equal to 4 points with respect to the weekly mean of the daily 24 hour I-NRS score at week 12.

It has come to the fore that the point occurrence of chronic pruritus in AD ranges between 87% and 100%. Seemingly, both psychosocial well-being and quality of life are known to correlate with the severity of the itch.

Source credit: http://ir.caratherapeutics.com/news-releases/news-release-details/cara-therapeutics-announces-initiation-phase-2-trial-oral-0

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

TPG Rise Climate Fund raises $5.4Bn to support new climate solutions
TPG Rise Climate Fund raises $5.4Bn to support new climate solutions
By Mateen Dalal

TPG Rise Climate Fund, the climate investing fund of TPG’s global impact investing platform TPG Rise, has recently raised its first close of $5.4 billion, bringing together an exclusive blend of funding from some of the top institutional invest...

Baby nutrition firm ByHeart nabs $90Mn in Series B funding round
Baby nutrition firm ByHeart nabs $90Mn in Series B funding round
By Mateen Dalal

ByHeart, a fully integrated infant nutrition company, has reportedly secured $90 million in Series B funding which the company plans to use for the launch of its baby formula and support the development of its pipeline of nutrition items for chi...

UAE extends travel ban for Indians amid strict COVID-19 guidelines
UAE extends travel ban for Indians amid strict COVID-19 guidelines
By Mateen Dalal

United Arab Emirates (UAE) has reportedly extended travel ban for individuals travelling from India and several other south Asian countries on the pretext of COVID-19 guidelines. As reported by Etihad Airlines, the ban will be followed till 31st July...