BioXcel adds Pfizer, Merck to pancreatic cancer therapy collaboration
Category: #health  By Mateen Dalal  Date: 2019-03-05
  • share
  • Twitter
  • Facebook
  • LinkedIn

BioXcel adds Pfizer, Merck to pancreatic cancer therapy collaboration

BioXcel Therapeutics, Inc. has made an announcement confirming the addition of Germany-based Merck KGaA as well as Pfizer Inc. to its clinical collaboration with Nektar Therapeutics for evaluating an innovative triple combination treatment for pancreatic cancer.

Reportedly, the collaboration would now include avelumab, which is co-developed and co-commercialized by Pfizer and Merck KGaA, BXCL701 developed by BioXcel and NKTR-214 which is developed by Nektar.

As part of the collaboration, BioXcel said it would be responsible for the initiation and management of the clinical program and Nektar would be supplying NKTR-214, with Merck KGaA and Pfizer supplying avelumab. All the development costs would equally be shared between BioXcel and Nektar.

The company has informed that primary objectives of the trial would be to evaluate the efficacy and safety of the triple combination consisting of avelumab, BXCL701 and NKTR-214 for treating patients suffering from pancreatic cancer. In addition, evaluation will also be done for correlative immune activation markets in tumor tissue and blood.

CEO of BioXcel Therapeutics, Mr. Vimal Mehta stated that the company believes expansion of this clinical collaboration offers certain evidence of the industry’s interest towards BXCL701. He mentioned that working closely with Pfizer and Merck KGaA along with Nektar Therapeutics, BioXcel would be leveraging their regulatory and clinical expertise as it looks to establish a development plan for the triple combination therapy in pancreatic cancer patients.

Jonathan Zalevsky, Nektar Therapeutics’ Chief Scientific Officer, said it is vital to target multiple dimensions of the immune system while also addressing the multi-faceted etiologies associated with cell cancer growth in pancreatic cancer and other hard-to-treat tumors.

Zalevsky further added that the experimental regimen of the triple combination of BXCL701, NKTR-214 and avelumab has been designed to leverage multiple action mechanisms for fighting pancreatic cancer better, while generating potentially long-term immunity to cancer.

  • share
  • Twitter
  • Facebook
  • LinkedIn


About Author

Mateen Dalal    

Mateen Dalal

Mateen has completed his Bachelor’s degree in electronics and telecommunication engineering, post which he lent his proficiency to the industry, working as a quality and test engineer. Drawn intricately toward the field of content creation however, Mateen soon switc...

Read More

More News By Mateen Dalal

Air France-KLM & JAL make bids to purchase stake in Malaysia Airlines
Air France-KLM & JAL make bids to purchase stake in Malaysia Airlines
By Mateen Dalal

Air France–KLM S.A., one of the leading global air transport players, has reportedly made a proposal to invest in Malaysia Airlines and gain around 49 percent stake. Japan Airlines (JAL) is also looking to acquire a 25 percent stake in Mal...

Accenture opens innovation center in South Beach Road office
Accenture opens innovation center in South Beach Road office
By Mateen Dalal

Accenture, an Irish multinational professional services company, has recently opened a global innovation center within the Accenture’s office at South Beach Road, which is supported by EDB (Economic Development Board) in Singapore. It will pro...

Verrica unveils positive data from VP-102 study in molluscum treatment
Verrica unveils positive data from VP-102 study in molluscum treatment
By Mateen Dalal

Findings from the study are being produced at the 17th Annual Winter Clinical Dermatology Conference in Kohala Coast The data indicated a considerable increase in the percentage of patients with lesion clearance in VP-102 group Verrica Pharmaceu...