Atara Biotherapeutics to present clinical results of Car T platform

By Pankaj Singh

	The firm is looking forward to its MSK collaborators’ clinical outcomes of a mesothelin-targeted autologous CAR T for patients suffering from advanced malignant pleural ailment
	 
	The event is slated to be held from March 29 to April 3 at Atlanta, Georgia


Atara Biotherapeutics, Inc. has reportedly declared that it would present the clinical safety and efficacy results of mesothelin-targeted CAR T and next-generation CAR T platform at the annual meeting of the American Association of Cancer Research (AACR). As per trusted sources, the clinical results are from Memorial Sloan Kettering Cancer Center.

According to a press release from Atara Biotherapeutics, the event is slated to be held from March 29 to April 3 at Atlanta, Georgia. For the record, Mesothelin is a solid tumor-related antigen which is expressed at higher levels on the surface of cells in hostile solid tumors including non-small cell lung cancer, pancreatic cancer, ovarian cancer, triple-negative breast cancer, and mesothelioma.

Global Head of Research and Development at Atara Biotherapeutics, Dietmar Berger, M.D., Ph.D. was reportedly quoted saying that the company has established one of the foremost CAR T portfolios. The pre-clinical results presented at the AACR show are encouraging and show the potential of the firm’s EBV-specific T cell platform to develop allogeneic, off-the-shelf CAT T immunotherapies, Berger further added.

Reportedly, Atara Biotherapeutics is looking forward to its MSK collaborators’ clinical outcomes of a mesothelin-targeted autologous CAR T to treat patients suffering from advanced malignant pleural ailment.

Preliminary outcomes from the MSK sponsored Stage 1 study (currently in progress) of a mesothelin-targeted CAR T immunotherapy for patients with malignant plural cancers were exhibited at the 2018 annual meeting of American Society of Gene and Cell Therapy.

Atara had signed an exclusive collaboration and license deal with MSK in Jan this year to create a mesothelin-targeted CAR T by utilizing PD-1 dominant negative receptor (DNR) and 1XX CAR signaling domain checkpoint inhibition technologies.